Palovarotene, CAS 410528-02-8

Palovarotene, CAS 410528-02-8, Stock 257g, Assay 98.86%, White powder, Water 0.14%, Single Impurity 0.22%.

Palovarotene

Palovarotene, also known as RO-3300074 and R-667, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema. Phase I clinical trials of palovarotene in patients with emphysema demonstrated that the drug is well tolerated, with improvements observed in markers of emphysema progression. Emphysema is characterized by the destruction of alveoli and alveolar ducts within the lungs. Retinoid signaling is believed to play a role in alveologenesis, with the retinoic acid receptor gamma thought to be required for alveolar formation.

Product Details:

Name: Palovarotene

CAS#: 410528-02-8

Chemical Formula: C27H30N2O2

Exact Mass: 414.2307

Molecular Weight: 414.549

Elemental Analysis: C, 78.23; H, 7.29; N, 6.76; O, 7.72

Specification:

Synonym: RO-3300074; RO 3300074; RO3300074; R-667; R 667; R667; Palovarotene

IUPAC/Chemical Name: 4-((1E)-2-(5,5,8,8-Tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl)benzoic acid

InChi Key: YTFHCXIPDIHOIA-DHZHZOJOSA-N

InChi Code: InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+

SMILES Code: O=C(O)C1=CC=C(/C=C/C2=C(CN3N=CC=C3)C=C4C(C)(C)CCC(C)(C)C4=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

HS Tariff Code: 2934.99.9001

Certification: