CAS 256373-96-3: CP-456773 sodium
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- CAS Number: 256373-96-3
- Stock: 451g
- Assay: 99.25%
CP-456773 sodium, CAS 256373-96-3
CP-456773 sodium, CAS 256373-96-3, Stock 451g, Assay 99.25%, White to off-white powder, EOS Med Chem is big manufacturer of CP-456773 sodium.
CP-456773, also known as MCC950 and CRID3, is a potent and selective cytokine release inhibitor and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases. CP-456773 inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced interleukin-1β (IL-1β) production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. MCC950 is a potential therapeutic for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases, and a tool for further study of the NLRP3 inflammasome in human health and disease.
Name: CP-456773 sodium
CAS#: 256373-96-3 (sodium)
Chemical Formula: C20H23N2NaO5S
Molecular Weight: 426.4628
Elemental Analysis: C, 56.33; H, 5.44; N, 6.57; Na, 5.39; O, 18.76; S, 7.52
Related CAS #: 256373-96-3 (sodium) 210826-40-7 (free acid)
Synonym: MCC950; MCC 950; MCC-950; CP-456773; CP456773; CP 456773; CRID-3; CRID3; CRID 3; CP-456773 sodium salt; Cytokine release inhibitory drug 3
IUPAC/Chemical Name: sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide
InChi Key: LFQQNXFKPNZRFT-UHFFFAOYSA-M
InChi Code: InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
SMILES Code: O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]
Appearance: Solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001