CAS 2110426-27-0 : JNJ-63576253

  • CAS 2110426-27-0 : JNJ-63576253

CAS 2110426-27-0 : JNJ-63576253
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 2110426-27-0
  • Stock: 231g
  • Assay: 99.34%

JNJ-63576253 , CAS 2110426-27-0

JNJ-63576253 , CAS 2110426-27-0, Stock 231g, Assay 99.34%, White to off-white powderEOS Med Chem is big manufacturer of JNJ-63576253.



JNJ-63576253 

JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells.



Product Details:

Name: JNJ-63576253

CAS#: 2110426-27-0 (free base)

Chemical Formula: C23H21F3N6O2S

Exact Mass: 502.1399

Molecular Weight: 502.5162

Elemental Analysis: C, 54.97; H, 4.21; F, 11.34; N, 16.72; O, 6.37; S, 6.38



Specification:

Related CAS #: 2110428-64-1 (HCl)   2110426-27-0 (free base)    

Synonym: TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253; JNJ 63576253;

IUPAC/Chemical Name: 5-(8-Oxo-5-(6-(piperidin-4-yloxy)pyridin-3-yl)-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)-picolinonitrile

InChi Key: OUEHJEYKNYQVRC-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H21F3N6O2S/c24-23(25,26)17-10-15(13-29-18(17)11-27)31-20(33)22(6-1-7-22)32(21(31)35)14-2-3-19(30-12-14)34-16-4-8-28-9-5-16/h2-3,10,12-13,16,28H,1,4-9H2

SMILES Code: N#CC1=NC=C(N(C2=O)C(N(C3=CC=C(OC4CCNCC4)N=C3)C52CCC5)=S)C=C1C(F)(F)F

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certifications: