CAS 2110426-27-0 : JNJ-63576253
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- CAS Number: 2110426-27-0
- Stock: 231g
- Assay: 99.34%
JNJ-63576253 , CAS 2110426-27-0
JNJ-63576253 , CAS 2110426-27-0, Stock 231g, Assay 99.34%, White to off-white powder, EOS Med Chem is big manufacturer of JNJ-63576253.
JNJ-63576253
JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells.
Product Details:
Name: JNJ-63576253
CAS#: 2110426-27-0 (free base)
Chemical Formula: C23H21F3N6O2S
Exact Mass: 502.1399
Molecular Weight: 502.5162
Elemental Analysis: C, 54.97; H, 4.21; F, 11.34; N, 16.72; O, 6.37; S, 6.38
Specification:
Related CAS #: 2110428-64-1 (HCl) 2110426-27-0 (free base)
Synonym: TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253; JNJ 63576253;
IUPAC/Chemical Name: 5-(8-Oxo-5-(6-(piperidin-4-yloxy)pyridin-3-yl)-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)-picolinonitrile
InChi Key: OUEHJEYKNYQVRC-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H21F3N6O2S/c24-23(25,26)17-10-15(13-29-18(17)11-27)31-20(33)22(6-1-7-22)32(21(31)35)14-2-3-19(30-12-14)34-16-4-8-28-9-5-16/h2-3,10,12-13,16,28H,1,4-9H2
SMILES Code: N#CC1=NC=C(N(C2=O)C(N(C3=CC=C(OC4CCNCC4)N=C3)C52CCC5)=S)C=C1C(F)(F)F
Appearance: Solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
