CAS 2109704-99-4 : Belumosudil mesylate
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- CAS Number: 2109704-99-4
- Stock: 211g
- Assay: 99.14%
Belumosudil mesylate, CAS 2109704-99-4
Belumosudil mesylate, CAS 2109704-99-4, Stock 211g, Assay 99.14%, White to off- white powder, EOS Med Chem is big manufacturer of Belumosudil mesylate.
Belumosudil, also known as KD-025 and WHO11343, is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. It is used in the treatment of Autoimmune Diseases. Belumosudil was approved in 2021 in USA To treat chronic graft-versus-host disease after failure of at least two prior lines of systemic therapy
Name: Belumosudil mesylate
CAS#: 2109704-99-4 (mesylate)
Chemical Formula: C27H28N6O5S
Molecular Weight: 548.62
Elemental Analysis: C, 59.11; H, 5.14; N, 15.32; O, 14.58; S, 5.84
Related CAS #: 911417-87-3 (free base) 2109704-99-4 (mesylate)
Synonym: Belumosudil mesylate; KD 025; KD-025; KD025; WHO11343; WHO-11343; WHO 11343; SLx 2119; SLx2119; SLx-2119;
IUPAC/Chemical Name: 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(propan-2-yl)acetamide methanesulfonate (1:1)
InChi Key: ILQJXEIRBCHLOM-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H24N6O2.CH4O3S/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22;1-5(2,3)4/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31);1H3,(H,2,3,4)
SMILES Code: O=C(NC(C)C)COC1=CC=CC(C2=NC(NC3=CC4=C(NN=C4)C=C3)=C5C=CC=CC5=N2)=C1.CS(=O)(O)=O
Appearance: Solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001