Alrizomadlin,CAS 1818393-16-6

Alrizomadlin,CAS 1818393-16-6, Stock 350g, Assay 98.80%, Solid powder, Water 0.20%, Single Impurity 0.15%.

Alrizomadlin

AA-115, also known as APG-115, is a highly potent, chemically stable and efficacious E3 ubiquitin-protein ligase Mdm2 (Hdm2) inhibitor, which has entered clinical development for cancer treatment. AA-115 has a very high affinity to MDM2 (Ki < 1 nM), potent cellular activity, and an excellent oral pharmacokinetic profile. Compound 60 is capable of achieving complete and longlasting tumor regression in vivo and is currently in phase I clinical trials for cancer treatment.

Product Details:

Name: AA-115

CAS#: 1818393-16-6

Chemical Formula: C34H38Cl2FN3O4

Exact Mass: 641.22

Molecular Weight: 642.593

Elemental Analysis: C, 63.55; H, 5.96; Cl, 11.03; F, 2.96; N, 6.54; O, 9.96

Specification:

Synonym: AA-115; AA 115; AA115; APG 115; APG115; APG-115; Alrizomadlin

IUPAC/Chemical Name: 4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic acid

InChi Key: YJCZPJQGFSSFOL-MNZPCBJKSA-N

InChi Code: InChI=1S/C34H38Cl2FN3O4/c1-2-40-27(28(41)39-32-16-13-31(14-17-32,15-18-32)30(43)44)25(21-7-6-8-23(36)26(21)37)34(33(40)11-4-3-5-12-33)22-10-9-20(35)19-24(22)38-29(34)42/h6-10,19,25,27H,2-5,11-18H2,1H3,(H,38,42)(H,39,41)(H,43,44)/t25-,27+,31?,32?,34+/m0/s1

SMILES Code: O=C1NC2=CC(Cl)=CC=C2[C@]13C4(CCCCC4)N(CC)[C@@H](C(NC5(CC6)CCC6(C(O)=O)CC5)=O)[C@@H]3C7=C(F)C(Cl)=CC=C7

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001