CAS 1562338-42-4 : Branaplam free base

CAS 1562338-42-4 : Branaplam free base
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  • CAS Number: 1562338-42-4
  • Stock: 207g
  • Assay: 98.15%

Branaplam free baseCAS 1562338-42-4:

Branaplam free baseCAS 1562338-42-4Stock 207g, Assay 98.15%, White powderWater 0.27%, Single Impurity 0.21%.

Branaplam free base,CAS 1562338-42-4

Branaplam, also known as NVS-SM1 and LMI-070, is a highly potent, selective and orally active small molecule SMN2 splicing modulator as a potential treatment for SMA Type 1 (Spinal Muscular Atrophy) .NVS-SM1 works by increasing the amount of functional SMN protein produced by the “back-up” gene, SMN2, through modifying its splicing.

Product Details:

Name: Branaplam free base

CAS#: 1562338-42-4 (free base)

Chemical Formula: C22H27N5O2

Exact Mass: 393.2165

Molecular Weight: 393.491

Elemental Analysis: C, 67.15; H, 6.92; N, 17.80; O, 8.13


Related CAS #: 1562338-42-4 (free base)   1562338-39-9 (HCl)   Branaplam mesylate    

Synonym: NVS-SM1; NVS SM1; NVSSM1; LMI-070; LMI070; LMI 070; Branaplam

IUPAC/Chemical Name: 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]-phenol


InChi Code: InChI=1S/C22H27N5O2/c1-21(2)10-16(11-22(3,4)27-21)29-20-8-7-18(25-26-20)17-6-5-14(9-19(17)28)15-12-23-24-13-15/h5-9,12-13,16,27-28H,10-11H2,1-4H3,(H,23,24)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001