CAS 152459-95-5: Imatinib free base

  • CAS 152459-95-5: Imatinib free base

CAS 152459-95-5: Imatinib free base
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 152459-95-5
  • Stock: 363g
  • Assay: 99.54%

Imatinib free base, CAS 152459-95-5

Imatinib free base, CAS 152459-95-5, Stock 363g, Assay 99.54%, Off-White powder, EOS Med Chem is big manufacturer of Imatinib free base.


Imatinib free base

Imatinib is a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Imatinib was approved for medical use in the United States in 2001.


Product Details:

Name: Imatinib free base

CAS#: 152459-95-5 (free base)

Chemical Formula: C29H31N7O

Exact Mass: 493.259

Molecular Weight: 493.615

Elemental Analysis: C, 70.56; H, 6.33; N, 19.86; O, 3.24


Specification:

Synonym: CGP 57148; CGP57148; CGP-57148; CGP57148B; CGP-57148B; CGP 57148B; STI571; STI-571; STI 571; Imatinib; US brand name: Gleevec. Foreign brand name: Glivec

IUPAC/Chemical Name: N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

InChi Key: KTUFNOKKBVMGRW-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)

SMILES Code: O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCN(C)CC5)C=C4

Appearance: white to off-white to brownish or yellowish tinged crystalline powder.

Purity: >99.54% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: