CAS 1523406-39-4 : SAR-405

CAS 1523406-39-4 : SAR-405
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  • CAS Number: 1523406-39-4
  • Stock: 352g
  • Assay: 99.47%

SAR-405, CAS 1523406-39-4

SAR-405, CAS 1523406-39-4, Stock 352g, Assay 99.47%, Off-White powder, EOS Med Chem is big manufacturer of SAR-405.


SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.

Product Details:

Name: SAR-405

CAS#: 1523406-39-4

Chemical Formula: C19H21ClF3N5O2

Exact Mass: 443.1336

Molecular Weight: 443.8552

Elemental Analysis: C, 51.42; H, 4.77; Cl, 7.99; F, 12.84; N, 15.78; O, 7.21


Synonym: SAR-405; SAR 405; SAR405.

IUPAC/Chemical Name: (S)-9-((5-chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one


InChi Code: InChI=1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21,22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9,12,15H,2-5,10-11H2,1H3/t12-,15+/m1/s1

SMILES Code: O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC4=CC(Cl)=CN=C4)[C@H](C(F)(F)F)CCN31

Appearance: Solid powder

Purity: >99.47% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001