CAS 130306-02-4: Tezacitabine
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- CAS Number: 130306-02-4
- Stock: 715g
- Assay: 99.29%
Tezacitabine, CAS 130306-02-4
Tezacitabine, CAS 130306-02-4, Stock 715g, Assay 99.29%, White powder, Water 0.38%, Single Impurity 0.33%.
Tezacitabine is a synthetic purine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, further compromising DNA replication.
Chemical Formula: C10H11FN2O4
Exact Mass: 242.07029
Molecular Weight: 242.2
Elemental Analysis: C, 49.59; H, 4.58; F, 7.84; N, 11.57; O, 26.42
Synonym: MDL 101731; FMdC; KW 2331; MDL 101731; KW2331; MDL101731;
IUPAC/Chemical Name: 1-((2R,4S,5R,E)-3-(fluoromethylene)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
InChi Key: CXVQYURZKMJITE-JZUREZDFSA-N
InChi Code: InChI=1S/C10H11FN2O4/c11-4-6-8(15)7(5-14)17-9(6)13-3-1-2-12-10(13)16/h1-4,7-9,14-15H,5H2/b6-4+/t7-,8+,9-/m1/s1
SMILES Code: O=C1N=CC=CN1[C@@H]2O[C@H](CO)[C@@H](O)/C2=C\F
Appearance: Solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in wate
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001