CAS 1301214-47-0: PF05175157

  • CAS 1301214-47-0: PF05175157

CAS 1301214-47-0: PF05175157
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1301214-47-0
  • Stock: 266g
  • Assay: 99.53%

PF05175157, CAS 1301214-47-0

PF05175157, CAS 1301214-47-0, Stock 266g, Assay 99.53%, White powderWater 0.22%, Single Impurity 0.25%.


PF-05175157 is a potent and selective cetyl-CoA carboxylase (ACC) 1 and 2 inhibitor with IC50 values of 27 nM and 33 nM, respectively. PF-05175157 led to robust reduction of de novo lipogenesis (DNL), albeit with concomitant reductions in platelet count, which were attributed to the inhibition of fatty acid synthesis within bone marrow. PF-05175157 induced a reduction of the viral load in serum and kidney in WNV-infected mice, unveiling its therapeutic potential for the treatment of chronic kidney disease associated with persistent WNV infection.

Product Details:

Name: PF05175157

CAS#: 1301214-47-0

Chemical Formula: C23H27N5O2

Exact Mass: 405.21648

Molecular Weight: 405.5

Elemental Analysis: C, 68.13; H, 6.71; N, 17.27; O, 7.89


Synonym: PF-05175157; PF05175157; PF 05175157.

IUPAC/Chemical Name: 1,4-Dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one


InChi Code: InChI=1S/C23H27N5O2/c1-14(2)28-21-17(13-24-28)11-23(12-20(21)29)6-8-27(9-7-23)22(30)16-4-5-18-19(10-16)26-15(3)25-18/h4-5,10,13-14H,6-9,11-12H2,1-3H3,(H,25,26)


Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001