CAS 1297538-32-9: ODM-201

  • CAS 1297538-32-9: ODM-201

CAS 1297538-32-9: ODM-201
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1297538-32-9
  • Stock: 116g
  • Assay: 99.32%

ODM-201, CAS 1297538-32-9

ODM-201, CAS 1297538-32-9, Stock 116g, Assay 99.32%, White powderWater 0.29%, Single Impurity 0.29%.


ODM-201

ODM-201, also known as Darolutamide, is a new-generation, potent and selective androgen receptor (AR) inhibitor which is potential useful for treatment of castration-resistant prostate cancer (CRPC). ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509, inhibits testosterone-induced nuclear translocation of AR. Importantly, ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies, including the F876L mutation that confers resistance to enzalutamide and ARN-509. In addition, ODM-201 reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model. ODM-201 overcomes resistance to AR-targeted therapies by antagonizing both overexpressed and mutated ARs. ODM-201 is currently in a phase 3 trial in CRPC.


Product Details:

Name: ODM-201

CAS#: 1297538-32-9

Chemical Formula: C19H19ClN6O2

Exact Mass: 398.1258

Molecular Weight: 398.85

Elemental Analysis: C, 57.22; H, 4.80; Cl, 8.89; N, 21.07; O, 8.02


Specification:

Synonym: ODM-201; ODM 201; ODM201; Darolutamide; Nubeqa.

IUPAC/Chemical Name: N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide

InChi Key: ANGUXJDGJCHGOG-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H29N5O/c1-19-8-9-22-23(27-19)6-3-7-24(22)29-16-14-28(15-17-29)12-10-20-4-2-5-21(18-20)30-13-11-26-25(30)31/h2-9,18H,10-17H2,1H3,(H,26,31)

SMILES Code: O=C(C1=NNC(C(O)C)=C1)N[C@@H](C)CN2N=C(C3=CC=C(C#N)C(Cl)=C3)C=C2

Appearance: White to off-white solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: