CAS 1285702-20-6：ML167
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ML167, CAS 1285702-20-6

ML167, CAS 1285702-20-6, Stock 219g, Assay 99.48%, White powder, Water 0.36%, Single Impurity 0.16%.

ML167

ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4. The Cdc2-like kinases (ClkÂ’s) and the dual-specificity tyrosine phosphorylation-regulated kinases (DyrkÂ’s) have specified roles in gene splicing. Specifically, the Clk class of enzymes has been shown to phosphorylate the serine- and arginine-rich (SR) proteins, which are a major component of the spliceosome.

Product Details:

Name: ML167

CAS#: 1285702-20-6

Chemical Formula: C19H17N3O3

Exact Mass: 335.127

Molecular Weight: 335.3566

Elemental Analysis: C, 68.05; H, 5.11; N, 12.53; O, 14.31

Specification:

Synonym: ML167; ML-167; ML 167; CID 44968231; CID44968231; CID-44968231; NCGC00188654; NCGC-00188654; NCGC 00188654

IUPAC/Chemical Name: (5-(4-(((5-methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol

InChi Key: ROCFOIBAEVAOLQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22)

SMILES Code: OCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: