CAS 1271022-90-2 : BMS-911543

CAS 1271022-90-2 : BMS-911543
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1271022-90-2
  • Stock: 547g
  • Assay: 99.28%

BMS-911543, CAS 1271022-90-2

BMS-9115439, CAS 1271022-90-2, Stock 547g, Assay 99.28%, White powderWater 0.42%, Single Impurity 0.3%.


BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS-911543 selectively inhibits JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.

Product Details:

Name: BMS-911543

CAS#: 1271022-90-2

Chemical Formula: C23H28N8O

Exact Mass: 432.23861

Molecular Weight: 432.52142

Elemental Analysis: C, 63.87; H, 6.53; N, 25.91; O, 3.70


Synonym: BMS911543; BMS-911543; BMS 911543.

IUPAC/Chemical Name: N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide


InChi Code: InChI=1S/C23H28N8O/c1-5-30-17(23(32)31(14-6-7-14)15-8-9-15)11-16-20-19(24-12-28(20)3)21(26-22(16)30)25-18-10-13(2)29(4)27-18/h10-12,14-15H,5-9H2,1-4H3,(H,25,26,27)

SMILES Code: O=C(C1=CC2=C(N(C)C=N3)C3=C(NC4=NN(C)C(C)=C4)N=C2N1CC)N(C5CC5)C6CC6

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001