CAS 1268524-70-4: (+)-JQ1
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(+)-JQ1, CAS 1268524-70-4

(+)-JQ1, CAS 1268524-70-4, Stock 554g, Assay 99.46%, White powder, Water 0.0.32%, Single Impurity 0.20%.

(+)-JQ1

(+)-JQ1 is a BET potent BET bromodomain Inhibitor. Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1 has antiproliferative activity against many cancers, mainly through inhibition of c-MYC and upregulation of p21. JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer. JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. JQ1 disrupts human dendritic cell maturation by inhibiting STAT5.

Product Details:

Name: (+)-JQ1

CAS#: 1268524-70-4

Chemical Formula: C23H25ClN4O2S

Exact Mass: 456.13867

Molecular Weight: 456.99

Elemental Analysis: C, 60.45; H, 5.51; Cl, 7.76; N, 12.26; O, 7.00; S, 7.02

Specification:

Synonym: (+)-JQ1; (+)-JQ-1; (+)-JQ 1; Bromodomain Inhibitor

IUPAC/Chemical Name: tert-butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

InChi Key: DNVXATUJJDPFDM-KRWDZBQOSA-N

InChi Code: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1

SMILES Code: O=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: