CAS 1262888-28-7 : Spautin-1
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- CAS Number: 1262888-28-7
- Stock: 623g
- Assay: 99.26%
Spautin-1, CAS 1262888-28-7
Spautin-1, CAS 1262888-28-7, Stock 739g, Assay 99.26%, White powder, Water 0.49%, Single Impurity 0.25%.
Spautin-1 is a novel and potent autophagy inhibitor, which enhances imatinib-induced (MI) apoptosis in chronic myeloid leukemia. Autophagy has been proposed to play a role in MI resistance. Spautin-1 markedly inhibits IM-induced autophagy in CML cells by downregulating Beclin-1. Spautin-1 enhances IM-induced CML cell apoptosis by reducing the expression of the anti-apoptotic proteins Mcl-1 and Bcl-2. Spautin-1 enhances IM-induced apoptosis by inactivating PI3K/AKT and activating downstream GSK3β, leading to downregulation of Mcl-1 and Bcl-2, which represents a promising approach to improve the efficacy of IM in the treatment of patients with CML.
Chemical Formula: C15H11F2N3
Exact Mass: 271.0921
Molecular Weight: 271.27
Elemental Analysis: C, 66.42; H, 4.09; F, 14.01; N, 15.49
Synonym: Spautin-1; Spautin1; Spautin 1.
IUPAC/Chemical Name: 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine
InChi Key: AWIVHRPYFSSVOG-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
SMILES Code: FC1=CC=C(CNC2=C3C=C(F)C=CC3=NC=N2)C=C1
Appearance: Solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001