CAS 1251906-10-1: AS2553627

  • CAS 1251906-10-1: AS2553627

CAS 1251906-10-1: AS2553627
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  • CAS Number: 1251906-10-1
  • Stock: 250g
  • Assay: 99.23%

AS2553627, CAS 1251906-10-1

AS2553627, CAS 1251906-10-1, Stock 250g, Assay 99.23%, White powder,EOS Med Chem is big manufacturer of AS2553627


AS2553627 is a novel JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts. AS2553627 potently inhibited JAK kinases but showed no inhibition of other kinases, including TCR-associated molecules. In a rat cardiac transplant model, oral administration of AS2553627 alone or co-administration with a sub-therapeutic dose of tacrolimus effectively prolonged cardiac allograft survival, suggesting the efficacy in treating acute rejection. AS2553627 may be a therapeutic candidate for the prevention of not only acute but also chronic rejection in cardiac transplantation.

Product Details:

Name: AS2553627

CAS#: 1251906-10-1

Chemical Formula: C18H19N5O

Exact Mass: 321.159

Molecular Weight: 321.384

Elemental Analysis: C, 67.27; H, 5.96; N, 21.79; O, 4.98


Synonym: AS2553627; AS-2553627; AS 2553627.

IUPAC/Chemical Name: 3-((3R,4R)-3-(dipyrrolo[2,3-b:2',3'-d]pyridin-1(6H)-yl)-4-methylpiperidin-1-yl)-3-oxopropanenitrile


InChi Code: InChI=1S/C18H19N5O/c1-12-4-8-22(16(24)2-6-19)11-15(12)23-9-5-13-10-21-18-14(17(13)23)3-7-20-18/h3,5,7,9-10,12,15H,2,4,8,11H2,1H3,(H,20,21)/t12-,15+/m1/s1

SMILES Code: N#CCC(N1C[C@H](N2C=CC3=CN=C(NC=C4)C4=C32)[C@H](C)CC1)=O

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001