daprodustat,GSK1278863, CAS 960539-70-2

  • daprodustat,GSK1278863, CAS 960539-70-2

daprodustat,GSK1278863, CAS 960539-70-2
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 960539-70-2
  • Stock: 600g
  • Assay: 98.55%

daprodustat,GSK1278863, CAS 960539-70-2

daprodustat,GSK1278863, CAS 960539-70-2 Stock 600g, Assay 98.55%, White powder, Water 0.24%, Single Impurity 0.32%.


GSK1278863

Daprodustat, also known as GSK1278863, is a novel HIF-prolyl hydroxylase inhibitor. Hypoxia inducible factor (HIF) stabilization by HIF-prolyl hydroxylase (PHD) inhibitors may improve ischemic conditions such as peripheral artery disease (PAD). Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease.



Product Details:

Name: Daprodustat

CAS#: 960539-70-2

Chemical Formula: C19H27N3O6

Exact Mass: 393.18999

Molecular Weight: 393.44

Elemental Analysis: C, 58.00; H, 6.92; N, 10.68; O, 24.40


Specification:

Synonym: GSK1278863; GSK 1278863; GSK-1278863; Daprodustat

IUPAC/Chemical Name: (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine

InChi Key: RUEYEZADQJCKGV-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)

SMILES Code: O=C(O)CNC(C(C(N1C2CCCCC2)=O)C(N(C3CCCCC3)C1=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO (3mg/mL), not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification:




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