Pacritinib(SB1518), CAS 937272-79-2

  • Pacritinib(SB1518), CAS 937272-79-2

Pacritinib(SB1518), CAS 937272-79-2
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 937272-79-2
  • Stock: 1.03kg
  • Assay: 98.86%

Pacritinib(SB1518), CAS 937272-79-2

Pacritinib(SB1518), CAS 937272-79-2Stock 1034g, Assay 98.86%, White powderWater 0.75%, Single Impurity 0.53%.


Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders; the JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617. The JAK-STAT signaling pathway is a major mediator of cytokine activity.

Product Details:

Name: Pacritinib (SB1518)

CAS#: 937272-79-2

Chemical Formula: C28H32N4O3

Exact Mass: 472.24744

Molecular Weight: 472.58

Elemental Analysis: C, 71.16; H, 6.83; N, 11.86; O, 10.16


Synonym: SB1518; SB 1518; SB-1518; Pacritinib.

IUPAC/Chemical Name: 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene


InChi Code: InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)/b4-3+


Appearance: White powder

Purity: >98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001