Belumosudil, CAS 911417-87-3

  • Belumosudil, CAS 911417-87-3

Belumosudil, CAS 911417-87-3
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 911417-87-3
  • Stock: 993g
  • Assay: 98.74%

Belumosudil, CAS 911417-87-3

Belumosudil, CAS 911417-87-3Stock 993g, Assay 98.74%, White powderWater 0.44%, Single Impurity 0.32%.


KD-025 and WHO11343

Belumosudil, also known as KD-025 and WHO11343, is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. It is used in the treatment of Autoimmune Diseases. Belumosudil was approved in 2021 in USA To treat chronic graft-versus-host disease after failure of at least two prior lines of systemic therapy

Product Details:

Name: Belumosudil free base

CAS#: 911417-87-3 (free base)

Chemical Formula: C26H24N6O2

Exact Mass: 452.1961

Molecular Weight: 452.52

Elemental Analysis: C, 69.01; H, 5.35; N, 18.57; O, 7.07


Specification:

Related CAS #: 911417-87-3 (free base)   2109704-99-4 (mesylate) 

Synonym: Belumosudil; KD 025; KD-025; KD025; WHO11343; WHO-11343; WHO 11343;

IUPAC/Chemical Name: Acetamide, 2-(3-(4-(1H-indazol-5-ylamino)-2-quinazolinyl)phenoxy)-N-(1-methylethyl)-

InChi Key: GKHIVNAUVKXIIY-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)

SMILES Code: O=C(NC(C)C)COC1=CC=CC(C2=NC(NC3=CC4=C(NN=C4)C=C3)=C5C=CC=CC5=N2)=C1

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: