Pevonedistat, CAS 905579-51-3

  • Pevonedistat, CAS 905579-51-3

Pevonedistat, CAS 905579-51-3
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 905579-51-3
  • Stock: 644g
  • Assay: 98.58%

Pevonedistat, CAS 905579-51-3

Pevonedistat, CAS 905579-51-3Stock 644g, Assay 98.58%, White powderWater 0.21%, Single Impurity 0.22%.


MLN-4924 and TAK-924

Pevonedistat, also known as MLN-4924 and TAK-924, is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP).


Product Details:

Name: Pevonedistat (MLN-4924)

CAS#: 905579-51-3 (free base)

Chemical Formula: C21H25N5O4S

Exact Mass: 443.16273

Molecular Weight: 443.52

Elemental Analysis: C, 56.87; H, 5.68; N, 15.79; O, 14.43; S, 7.23


Specification:

Related CAS #: 1160295-21-5 (HCl)   905579-51-3 (free base)    

Synonym: TAK-924; TAK 924; TAK924; MLN4924; MLN 4924; BAY-73-4506; BAY 73-4506; BAY73-4506; Pevonedistat.

IUPAC/Chemical Name: ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate

InChi Key: MPUQHZXIXSTTDU-QXGSTGNESA-N

InChi Code: InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1

SMILES Code: O=S(OC[C@H]1[C@@H](O)C[C@H](N2C=CC3=C(N[C@H]4CCC5=C4C=CC=C5)N=CN=C32)C1)(N)=O

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not soluble in water.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO.

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: