CAS 867331-82-6: TG100801
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TG100801, CAS 867331-82-6:

TG100801, CAS 867331-82-6, Stock 109g, Assay 98.17%, White powder, Water 0.23%, Single Impurity 0.26%.

TG100801, CAS 867331-82-6

TG100801 or TG-100801 is a dual inhibitor of both VEGFr2 and the Src family (Src and YES) kinases as a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration. TG100801 is a multi-kinases inhibitor. It is a pro-drug version of TG100572. Age-related macular degeneration (AMD) is the leading cause of blindness in the Western world for those patients aged 50 years or older.

Product Details:

Name: TG100801

CAS#: 867331-82-6 (free base)

Chemical Formula: C33H30ClN5O3

Exact Mass: 579.2037

Molecular Weight: 580.085

Elemental Analysis: C, 68.33; H, 5.21; Cl, 6.11; N, 12.07; O, 8.27

Specification:

Related CAS #: 867331-82-6 (free base)   1018069-81-2 (HCl)    

Synonym: TG100801; TG-100801; TG 100801.

IUPAC/Chemical Name: 4-chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)benzo[e][1,2,4]triazin-7-yl)phenyl benzoate

InChi Key: JMGXJHWTVBGOKG-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H30ClN5O3/c1-22-19-24(28-21-27(13-14-29(28)34)42-32(40)23-7-3-2-4-8-23)20-30-31(22)36-33(38-37-30)35-25-9-11-26(12-10-25)41-18-17-39-15-5-6-16-39/h2-4,7-14,19-21H,5-6,15-18H2,1H3,(H,35,36,38)

SMILES Code: CC1=C2C(=CC(=C1)C3=C(C=CC(=C3)OC(=O)C4=CC=CC=C4)Cl)N=NC(=N2)NC5=CC=C(C=C5)OCCN6CCCC6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: