Ponesimod, CAS 854107-55-4

  • Ponesimod, CAS 854107-55-4

Ponesimod, CAS 854107-55-4
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 854107-55-4
  • Stock: 791g
  • Assay: 98.64%

Ponesimod, CAS 854107-55-4

Ponesimod, CAS 854107-55-4Stock 791g, Assay 98.64%, White powderWater 0.34%, Single Impurity 0.32%.


ACT-128800

Ponesimod, also known as ACT-128800, is a potent, and orally active selective S1P(1) agonist. Ponesimod activated S1P(1)-mediated signal transduction with high potency (EC(50) of 5.7 nM) and selectivity. Ponesimod prevented edema formation, inflammatory cell accumulation, and cytokine release in the skin of mice with delayed-type hypersensitivity. Ponesimod also prevented the increase in paw volume and joint inflammation in rats with adjuvant-induced arthritis. Ponesimod may represent a new therapeutic approach in lymphocyte-mediated autoimmune diseases.



Product Details:

Name: Ponesimod

CAS#: 854107-55-4

Chemical Formula: C23H25ClN2O4S

Exact Mass: 460.12236

Molecular Weight: 460.97

Elemental Analysis: C, 59.93; H, 5.47; Cl, 7.69; N, 6.08; O, 13.88; S, 6.95


Specification:

Synonym: ACT-128800; ACT 128800; ACT128800; Ponesimod.

IUPAC/Chemical Name: (Z)-5-((Z)-3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one

InChi Key: LPAUOXUZGSBGDU-STDDISTJSA-N

InChi Code: InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m1/s1

SMILES Code: O=C1N(C2=CC=CC=C2C)/C(S/C1=C\C3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: