MDL72274(HCl), CAS 85278-24-6
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MDL72274(HCl), CAS 85278-24-6

MDL72274(HCl), CAS 783355-60-2, Stock 693g, Assay 98.38%, White powder, Water 0.24%, Single Impurity 0.16%.

MDL72274(HCl)

MDL-72274 HCl is selective and potent inhibitors of SSAO for treatment of Parkinson diseases. MDL-72974 is a potent (IC50 = 10(-9) M) inhibitor of both MAO-B and SSAO, with 190-fold lower affinity for MAO-A. In clinical studies, oral doses as low as 100 micrograms produced substantial inhibition of platelet MAO-B. One or 4 mg MDL-72274 HCl given daily for 28 days to 40 Parkinson's patients treated with L-dopa produced statistically significant reductions in the Unified Parkinson's Disease Rating Scale. MAO-B inhibitors, such as MDL 72974A and L-deprenyl, offer the potential of being neuroprotective in Parkinson's Disease and other neurogenerative disorders.

Product Details:

Name: MDL-72274 HCl

CAS#: 85278-24-6

Chemical Formula: C9H11Cl2N

Exact Mass:

Molecular Weight: 204.094

Elemental Analysis: C, 52.97; H, 5.43; Cl, 34.74; N, 6.86

Specification:

IUPAC/Chemical Name: (E)-3-chloro-2-phenylprop-2-en-1-amine hydrochloride

InChi Key: KSVZCVSJFUUXGT-BORNJIKYSA-N

InChi Code: InChI=1S/C9H10ClN.ClH/c10-6-9(7-11)8-4-2-1-3-5-8;/h1-6H,7,11H2;1H/b9-6-;

SMILES Code: NC/C(C1=CC=CC=C1)=C/Cl.[H]Cl

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: