Encequidar, CAS 849675-66-7

  • Encequidar, CAS 849675-66-7

Encequidar, CAS 849675-66-7
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 849675-66-7
  • Stock: 904g
  • Assay: 98.54%

Encequidar, CAS 849675-66-7

Encequidar, CAS 849675-66-7Stock 904g, Assay 98.54%, White powderWater 0.24%, Single Impurity 0.32%.


HM-30181

Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). Encequidar is currently under clinical trials.


Product Details:

Name: Encequidar free base

CAS#: 849675-66-7 (free base)

Chemical Formula: C38H36N6O7

Exact Mass: 688.2645

Molecular Weight: 688.741

Elemental Analysis: C, 66.27; H, 5.27; N, 12.20; O, 16.26


Specification:

Related CAS #: 849675-66-7 (free base)   849675-87-2 (mesylate)   849675-88-3 (HCl)    

Synonym: Encequidar; HM-30181 free base; HM30181; HM-30181; HM 30181.

IUPAC/Chemical Name: N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide

InChi Key: AHJUHHDDCJQACA-UHFFFAOYSA-N

InChi Code: InChI=1S/C38H36N6O7/c1-47-32-17-24-14-16-43(22-25(24)18-33(32)48-2)15-13-23-9-11-26(12-10-23)44-41-37(40-42-44)28-19-34(49-3)35(50-4)20-29(28)39-38(46)36-21-30(45)27-7-5-6-8-31(27)51-36/h5-12,17-21H,13-16,22H2,1-4H3,(H,39,46)

SMILES Code: O=C(C1=CC(C2=C(O1)C=CC=C2)=O)NC3=CC(OC)=C(OC)C=C3C4=NN(C5=CC=C(CCN6CC7=C(C=C(OC)C(OC)=C7)CC6)C=C5)N=N4

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: