Palbociclib Isethionate, CAS 827022-33-3

  • Palbociclib Isethionate, CAS 827022-33-3

Palbociclib Isethionate, CAS 827022-33-3
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 827022-33-3
  • Stock: 903g
  • Assay: 98.37%

Palbociclib Isethionate, CAS 827022-33-3

Palbociclib Isethionate, CAS 827022-33-3, Stock 903g, Assay 98.37%, White powder, Water 0.58%, Single Impurity 0.59%.


Palbociclib Isethionate

Palbociclib, also known as PD0332991, is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation; inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation. PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50 = 0.011 μmol/L) and Cdk6 (IC50 = 0.016 μmol/L), having no activity against a panel of 36 additional protein kinases. Isethionate was approved on 2/3/2015 for treatment of advanced (metastatic) breast cancer.


Product Details:

Name: Palbociclib Isethionate

CAS#: 827022-33-3 (isethionate)

Chemical Formula: C26H35N7O6S

Exact Mass:

Molecular Weight: 573.67

Elemental Analysis: C, 54.44; H, 6.15; N, 17.09; O, 16.73; S, 5.59


Specification:

Synonym: PD 0332991; PD-0332991; PD0332991; PD0332991; PD332991; PD-332991; PD 332991; Palbociclib Isethionate, brand name: Ibrance

IUPAC/Chemical Name: 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxyethane-1-sulfonate

InChi Key: LYYVFHRFIJKPOV-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H29N7O2.C2H6O4S/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;3-1-2-7(4,5)6/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);3H,1-2H2,(H,4,5,6)

SMILES Code: O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5.OCCS(=O)(O)=O

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: