LY2157299,Galunisertib , CAS 700874-72-2

  • LY2157299,Galunisertib , CAS 700874-72-2

LY2157299,Galunisertib , CAS 700874-72-2
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 700874-72-2
  • Stock: 1.46kg
  • Assay: 98.43%

LY2157299,Galunisertib , CAS 700874-72-2

LY2157299,Galunisertib, CAS 700874-72-2, Stock 1463g, Assay 98.43%, White powderWater 0.73%, Single Impurity 0.26%.


Galunisertib, also known as LY2157299, is a novel, selective small molecule transforming growth factor beta receptor (TGF-βR) kinase inhibitor. LY2157299 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2157299 inhibited HCC migration and cell growth independently of the expression levels of TGF-βRII.

Product Details:

Name: Galunisertib

CAS#: 700874-72-2 (free base)

Chemical Formula: C22H19N5O

Exact Mass: 369.15896

Molecular Weight: 369.42

Elemental Analysis: C, 71.53; H, 5.18; N, 18.96; O, 4.33


Synonym: LY2157299; LY-2157299; LY 2157299; Galunisertib

IUPAC/Chemical Name: 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide


InChi Code: InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)

SMILES Code: O=C(C1=CC=C2N=CC=C(C3=C(CCC4)N4N=C3C5=NC(C)=CC=C5)C2=C1)N

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001