Neratinib, CAS 698387-09-6

  • Neratinib, CAS 698387-09-6

Neratinib, CAS 698387-09-6
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 698387-09-6
  • Stock: 789g
  • Assay: 98.78%

Neratinib, CAS 698387-09-6

Neratinib, CAS 698387-09-6Stock 739g, Assay 98.78%, White powderWater 0.34%, Single Impurity 0.42%.

HKI-272 or PB272

Neratinib, also known as HKI-272 or PB272, is an orally available, irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor.

Product Details:

Name: Neratinib

CAS#: 698387-09-6 (free base)

Chemical Formula: C30H29ClN6O3

Exact Mass: 556.19897

Molecular Weight: 557.04

Elemental Analysis: C, 64.68; H, 5.25; Cl, 6.36; N, 15.09; O, 8.62


Related CAS #: 698387-09-6 (free base)   915942-22-2 (maleate)    

Synonym: HKI272; HKI 272; HKI-272; PB272; PB 272; PB-272; Neratinib; Nerlynx

IUPAC/Chemical Name: (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide


InChi Code: InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+


Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001