Nintedanib (Bibf 1120), CAS 656247-17-5

  • Nintedanib (Bibf 1120), CAS 656247-17-5

Nintedanib (Bibf 1120), CAS 656247-17-5
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 656247-17-5
  • Stock: 661g
  • Assay: 98.61%

Nintedanib (Bibf 1120), CAS 656247-17-5

Nintedanib (Bibf 1120), CAS 656247-17-5Stock 661g, Assay 98.61%, White powderWater 0.24%, Single Impurity 0.32%.


BIBF 1120

Nintedanib, also known as BIBF 1120, is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR). Intedanib selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration. On 11/15/2014 , FDA approved Nintedanib for the treatment of idiopathic pulmonary fibrosis (IPF).



Product Details:

Name: Nintedanib

CAS#: 656247-17-5 (free base)

Chemical Formula: C31H33N5O4

Exact Mass: 539.25325

Molecular Weight: 539.62

Elemental Analysis: C, 69.00; H, 6.16; N, 12.98; O, 11.86


Specification:

Related CAS #: 656247-18-6 (esylate)   656247-17-5 (free base)   928326-83-4 (free base)    

Synonym: BIBF1120; BIBF 1120; BIBF-1120; Nintedanib. Brand name: Vargatef.

IUPAC/Chemical Name: (Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

InChi Key: XZXHXSATPCNXJR-ZIADKAODSA-N

InChi Code: InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-

SMILES Code: O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)OC

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: