VX-680(Tozasertib), CAS 639089-54-6

  • VX-680(Tozasertib), CAS 639089-54-6

VX-680(Tozasertib), CAS 639089-54-6
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 639089-54-6
  • Stock: 811g
  • Assay: 98.68%

VX-680(Tozasertib), CAS 639089-54-6

VX-680(Tozasertib), CAS 639089-54-6Stock 811g, Assay 98.68%, White powderWater 0.24%, Single Impurity 0.32%.


Tozasertib (VX-680) 

Tozasertib, also known as VX-680, MK0457 or VE465, is a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis.


Product Details:

Name: Tozasertib (VX-680)

CAS#: 639089-54-6

Chemical Formula: C23H28N8OS

Exact Mass: 464.21068

Molecular Weight: 464.59

Elemental Analysis: C, 59.46; H, 6.07; N, 24.12; O, 3.44; S, 6.90



Specification:

Synonym: VX680; VX 680; VX-680; MK0457; MK 0457; MK-0457; VE465; VE-465; VE 465; Tozasertib

IUPAC/Chemical Name: (N-[4({4-(4-methylpiperazin-1-yl)-6-[(3-methyl-1H-pyrazol-5 -yl)amino]pyrimidin-2-yl}thio)phenyl]cyclopropanecarboxamide)

InChi Key: GCIKSSRWRFVXBI-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)

SMILES Code: O=C(C1CC1)NC2=CC=C(SC3=NC(NC4=CC(C)=NN4)=CC(N5CCN(C)CC5)=N3)C=C2

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: