CAS 572924-54-0: Ridaforolimus
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Ridaforolimus, CAS 572924-54-0

Ridaforolimus CAS 572924-54-0, Stock 479g, Assay 99.7%, White powder, Water 0.11%, Single Impurity 0.3%.

Ridaforolimus

Ridaforolimus, also known as AP23573, is an investigational small-molecule inhibitor of mTOR, a protein that acts as a central regulator of protein synthesis, cell proliferation, cell cycle progression and cell survival. mTOR integrates signals from proteins, such as PI3K, AKT and PTEN known to be important to malignancy. Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and angiogenesis. It has had promising results in a clinical trial for advanced soft tissue and bone sarcoma.

Product Details:

Name: Ridaforolimus

CAS#: 572924-54-0

Chemical Formula: C53H84NO14P

Exact Mass: 989.56294

Molecular Weight: 990.21

Elemental Analysis: C, 64.29; H, 8.55; N, 1.41; O, 22.62; P, 3.13

Specification:

Synonym: AP23573; AP 23573; AP-23573; MK8669; MK 8669; MK-8669; Deforolimus, Ridaforolimus

IUPAC/Chemical Name: (1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28Z,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl dimethylphosphinate

InChi Key: BUROJSBIWGDYCN-QVXCGEACSA-N

InChi Code: InChI=1S/C53H84NO14P/c1-32-18-14-13-15-19-33(2)44(63-8)30-40-23-21-38(7)53(61,67-40)50(58)51(59)54-25-17-16-20-41(54)52(60)66-45(35(4)28-39-22-24-43(46(29-39)64-9)68-69(11,12)62)31-42(55)34(3)27-37(6)48(57)49(65-10)47(56)36(5)26-32/h13-15,18-19,27,32,34-36,38-41,43-46,48-49,57,61H,16-17,20-26,28-31H2,1-12H3/b15-13+,18-14+,33-19-,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

SMILES Code: O=P(C)(C)O[C@H]1[C@H](OC)C[C@H](C[C@H]([C@H](CC([C@H](C)/C=C(C)/[C@@H](O)[C@H]2OC)=O)OC([C@]3([H])CCCCN3C(C([C@@](O4)(O)[C@H](C)CC[C@@]4([H])C[C@H](OC)/C(C)=C\C=C\C=C\[C@@H](C)C[C@@H](C)C2=O)=O)=O)=O)C)CC1

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: soluble in DMSO, not soluble in water.

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: