EX-527(Selisistat), CAS 49843-98-3

EX-527(Selisistat), CAS 49843-98-3, Stock 999g, Assay 98.69%, White powder, Water 0.23%, Single Impurity 0.35%.

EX-527

Selisistat, also known as EX-527, is a SirT1 inhibitor for treatment of Huntington's disease. EX-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Galectin-9 in Combination With EX-527 Prolongs the Survival of Cardiac Allografts in Mice After Cardiac Transplantation. Ex-527 is widely used as a major inhibitor of Sirtuin enzymes, which are a family of highly conserved protein deacetylases and have been linked with caloric restriction and aging by modulating energy metabolism, genomic stability, and stress resistance.

Product Details:

Name: Selisistat

CAS#: 49843-98-3

Chemical Formula: C13H13ClN2O

Exact Mass: 248.0716

Molecular Weight: 248.71

Elemental Analysis: C, 62.78; H, 5.27; Cl, 14.25; N, 11.26; O, 6.43

Specification:

Synonym: EX-527; EX-527; EX-527; Selisistat.

IUPAC/Chemical Name: 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

InChi Key: FUZYTVDVLBBXDL-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)

SMILES Code: O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: