Lurbinectedin, CAS 497871-47-3

  • Lurbinectedin, CAS 497871-47-3

Lurbinectedin, CAS 497871-47-3
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 497871-47-3
  • Stock: 813g
  • Assay: 98.92%

Lurbinectedin, CAS 497871-47-3

Lurbinectedin, CAS 497871-47-3Stock 813g, Assay 98.92%, White powderWater 0.26%, Single Impurity 0.72%.


Lurbinectedin

Lurbinectedin, also known as PM01183, is a synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. DNA minor groove-binding agent PM01183 covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death. Lurbinectedin is a marine-derived covalent DNA binder, approved in 2020.


Product Details:

Name: Lurbinectedin

CAS#: 497871-47-3

Chemical Formula: C41H44N4O10S

Exact Mass: 784.2778

Molecular Weight: 784.88

Elemental Analysis: C, 62.74; H, 5.65; N, 7.14; O, 20.38; S, 4.08


Specification:

Synonym: Lurbinectedin; PM01183; PM-01183; PM 01183;

IUPAC/Chemical Name: PM-01183, (1'R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-2',3',4',6,6a,7,9'-decahydro-8,14-dihydroxy-6',9-dimethoxy-4,10,23-trimethyl-spiro(6,16-(epithiopropaneoxymethano)-7.13-imino-12H-1,3-dioxolo[7,8]soquino[3,2-b][3]benzazocine-20,1'-[1H]pyrido[3,4-b]indol]-19-one

InChi Key: YDDMIZRDDREKEP-HWTBNCOESA-N

InChi Code: 1S/C41H44N4O10S/c1-17-11-20-12-25-39(48)45-26-14-52-40(49)41(38-22(9-10-42-41)23-13-21(50-5)7-8-24(23)43-38)15-56-37(31(45)30(44(25)4)27(20)32(47)33(17)51-6)29-28(26)36-35(53-16-54-36)18(2)34(29)55-19(3)46/h7-8,11,13,25-26,30-31,37,39,42-43,47-48H,9-10,12,14-16H2,1-6H3/t25-,26-,30+,31+,37+,39-,41+/m0/s1

SMILES Code: Cc1cc2c(c(c1OC)O)[C@@H]3[C@@H]4[C@H]5c6c(c7c(c(c6OC(=O)C)C)OCO7)[C@@H](N4[C@H]([C@H](C2)N3C)O)COC(=O)[C@@]8(CS5)c9c(c1cc(ccc1[nH]9)OC)CCN8

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: