Lenvatinib (E7080), CAS 417716-92-8

  • Lenvatinib (E7080), CAS 417716-92-8

Lenvatinib (E7080), CAS 417716-92-8
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 417716-92-8
  • Stock: 852g
  • Assay: 98.84%

Lenvatinib (E7080), CAS 417716-92-8

Lenvatinib (E7080), CAS 417716-92-8Stock 852g, Assay 98.84%, White powderWater 0.24%, Single Impurity 0.32%.


E7080

Lenvatinib, also known as E7080, is a synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. E7080 blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis.


Product Details:

Name: Lenvatinib free base

CAS#: 417716-92-8 (free base)

Chemical Formula: C21H19ClN4O4

Exact Mass: 426.1095

Molecular Weight: 426.857

Elemental Analysis: C, 59.09; H, 4.49; Cl, 8.30; N, 13.13; O, 14.99


Specification:

Related CAS #: 857890-39-2 (mesylate)   417716-92-8 (free base)    

Synonym: Lenvatinib free base; E7080; E-7080; E 7080; ER-203492-00; Lenvatinib; Lenvatinib mesylate; trade name Lenvima.

IUPAC/Chemical Name: 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide

InChi Key: WOSKHXYHFSIKNG-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)

SMILES Code: O=C(C1=C(OC)C=C2N=CC=C(OC3=CC=C(NC(NC4CC4)=O)C(Cl)=C3)C2=C1)N

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: