GS-7340, CAS 379270-37-8

GS-7340, CAS 379270-37-8, Stock 976g, Assay 98.74%, White powder, Water 0.44%, Single Impurity 0.31%.

TAF and GS-7340

Tenofovir alafenamide, also known as TAF and GS-7340, is a nucleotide reverse transcriptase inhibitor (NRTIs) and a novel prodrug of tenofovir. By blocking reverse transcriptase, TAF prevent HIV from multiplying and can reduce the amount of HIV in the body. Tenofovir alafenamide is a prodrug, which means that it is an inactive drug. In the body, tenofovir alafenamide is converted to tenofovir diphosphate (TFV-DP). Tenofovir alafenamide fumarate was approved in November 2015 for treatment of HIV-1.

Product Details:

Name: Tenofovir alafenamide (free base)

CAS#: 379270-37-8 (free base)

Chemical Formula: C21H29N6O5P

Exact Mass: 476.1937

Molecular Weight: 476.47

Elemental Analysis: C, 52.94; H, 6.13; N, 17.64; O, 16.79; P, 6.50

Specification:

Related CAS #: 379270-38-9 (fumarate)   1392275-56-7 (hemifumarate)   379270-37-8 (free base)  

Synonym: GS7340; GS-7340; GS 7340; TAF; Tenofovir alafenamide; Genvoya.

IUPAC/Chemical Name: (S)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate

InChi Key: LDEKQSIMHVQZJK-AZFZMOAFSA-N

InChi Code: InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33?/m1/s1

SMILES Code: C[C@H](N[P@@](OC1=CC=CC=C1)(CO[C@H](C)CN2C=NC3=C(N)N=CN=C23)=O)C(OC(C)C)=O

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: