L-778123HCL, CAS 253863-00-2

  • L-778123HCL, CAS 253863-00-2

L-778123HCL, CAS 253863-00-2
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  • CAS Number: 253863-00-2
  • Stock: 1.45kg
  • Assay: 98.53%

L-778123HCL, CAS 253863-00-2

L-778123HCL, CAS 253863-00-2, Stock 1452g, Assay 98.53%, White powderWater 0.26%, Single Impurity 0.45%.


L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.

Product Details:

Name: L-778123 HCl

CAS#: 253863-00-2 (HCl)

Chemical Formula: C22H21Cl2N5O

Exact Mass:

Molecular Weight: 442.34

Elemental Analysis: C, 59.74; H, 4.79; Cl, 16.03; N, 15.83; O, 3.62


Synonym: L778123; L-778123; L 778123; L778,123; L-778,123; L 778,123 HCl; L-778123 hydrochloride

IUPAC/Chemical Name: 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride


InChi Code: InChI=1S/C22H20ClN5O.ClH/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18;/h1-7,10,12,16H,8-9,13-15H2;1H

SMILES Code: N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1.[H]Cl

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001