Adagrasib, CAS 2326521-71-3

Adagrasib, CAS 2326521-71-3, Stock 640g, Assay 98.35%, White powder, Water 0.34%, Single Impurity 0.32%.

Adagrasib

Adagrasib, also known as MRTX849, is a potent, highly selective, oral available KRAS G12C inhibitor. MRTX849 maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death. MRTX849 exhibited significantly improved half-life and penetration into the tumor, shutting down KRAS signaling for the entire dosing interval, and showing a higher degree of antitumor activity than previous KRAS mutant-selective inhibitors.

Product Details:

Name: MRTX849

CAS#: 2326521-71-3

Chemical Formula: C32H35ClFN7O2

Exact Mass: 603.2525

Molecular Weight: 604.13

Elemental Analysis: C, 63.62; H, 5.84; Cl, 5.87; F, 3.14; N, 16.23; O, 5.30

Specification:

Synonym: MRTX849; MRTX-849; MRTX 849; Adagrasib;

IUPAC/Chemical Name: 2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile

InChi Key: PEMUGDMSUDYLHU-ZEQRLZLVSA-N

InChi Code: InChI=1S/C32H35ClFN7O2/c1-21(34)31(42)41-17-16-40(18-23(41)11-13-35)30-25-12-15-39(28-10-4-7-22-6-3-9-26(33)29(22)28)19-27(25)36-32(37-30)43-20-24-8-5-14-38(24)2/h3-4,6-7,9-10,23-24H,1,5,8,11-12,14-20H2,2H3/t23-,24-/m0/s1

SMILES Code: O=C(C(F)=C)N([C@@H](CC#N)C1)CCN1C2=NC(OC[C@H]3N(C)CCC3)=NC4=C2CCN(C5=CC=CC6=C5C(Cl)=CC=C6)C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

HS Tariff Code: 2934.99.9001

Certification: