Sotorasib, AMG-510, 2252403-56-6, 2296729-00-3

  • Sotorasib, AMG-510, 2252403-56-6,  2296729-00-3

Sotorasib, AMG-510, 2252403-56-6, 2296729-00-3
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 2252403-56-6
  • Stock: 821g
  • Assay: 98.74%

Sotorasib, AMG-510, 2252403-56-6,  2296729-00-3

Sotorasib, AMG-510, 2252403-56-6,  2296729-00-3Stock 821g, Assay 98.64%, White powderWater 0.24%, Single Impurity 0.32%.

Sotorasib (AMG-510)

Sotorasib, also known as also known as AMG-510, is a potent KRAS G12C covalent inhibitor and the active atropisomer separated by chiral HPLC. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells. Note: According to Sci-Finder database, CAS#2252403-56-6 is a AMG510 active atropisomer. Many vendor mistakenly listed CAS#2296729-00-3 as the AMG510 active atropisomer.

Sotorasib Intermediate, stock like below:

Sotorasib Intermediate, 82671-06-5, Stock 11.2kg, Assay 99.4%, White powder

Sotorasib Intermediate, 113237-20-0, Stock 10.9kg, Assay 99.8%, White powder

Sotorasib Intermediate, 1698293-93-4, Stock 7.6kg, Assay 99.2%, White powder

Sotorasib Intermediate, 2252403-81-7, Stock 14.8kg, Assay 99.4%, White powder

Sotorasib Intermediate, 2252403-82-8, Stock 9.4kg, Assay 99.5%, White powder

Sotorasib Intermediate, 147081-29-6, Stock 8.6kg, Assay 99.7%, White powder

Sotorasib Intermediate, 1256345-60-4, Stock 7.2kg, Assay 99.3%, White powder

Sotorasib Intermediate, 763114-26-7, Stock 11.2kg, Assay 99.7%, White powder

Sotorasib Intermediate, 1021298-67-8, Stock 14.1kg, Assay 99.2%, White powder

Sotorasib Intermediate, 59878-57-8, Stock 13kg, Assay 99.2%, White powder

Sotorasib Intermediate, 2300966-23-6, Stock 11.6kg, Assay 99.3%, White powder

Sotorasib Intermediate, 2387555-31-7, Stock 10.7kg, Assay 99.2%, White powder

Sotorasib Intermediate, 2252403-85-1, Stock 10kg, Assay 99.1%, White powder

Product Details:

Name: Sotorasib (AMG-510)

CAS#: 2252403-56-6

Chemical Formula: C30H30F2N6O3

Exact Mass: 560.2347

Molecular Weight: 560.61

Elemental Analysis: C, 64.28; H, 5.39; F, 6.78; N, 14.99; O, 8.56


Related CAS #: 2296729-00-3 (racemate)   2252403-56-6   2296729-66-1   2387559-45-5   Unknown (HCl)    

Synonym: AMG-510; AMG 510; AMG510; Sotorasib,

IUPAC/Chemical Name: 4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one


InChi Code: InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

SMILES Code: O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001