AT-527, CAS 2241337-84-6

  • AT-527, CAS 2241337-84-6

AT-527, CAS 2241337-84-6
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 2241337-84-6
  • Stock: 960g
  • Assay: 99.99%

AT-527, CAS 2241337-84-6

AT-527, CAS 2241337-84-6, Stock 960g, Assay 99.99%. COVID New Drug.


AT-527, a hemisulfate salt of AT-511, a guanosine nucleotide prodrug, is a potent and orally active HCV viral replication inhibitor. AT-511 is a prodrug form of the antiviral nucleoside analog AT-9010. It reduces the infectious virus yield in cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome CoV (SARS-CoV), SARS-CoV-2, human CoV 229E (HCoV-229E), and HCoV-OC43 (EC90s = 37, 0.47, 2.8, 1.2, and 0.5 µM, respectively).

Product Details:

Name: AT-527

CAS#: 2241337-84-6 (hemisulfate)

Chemical Formula: C48H68F2N14O18P2S

Exact Mass:

Molecular Weight: 1261.1563

Elemental Analysis: C, 45.71; H, 5.44; F, 3.01; N, 15.55; O, 22.83; P, 4.91; S, 2.54


Synonym: AT 527; AT-527; AT527; RG 6422; RG-6422; RG6422

IUPAC/Chemical Name: isopropyl ((S)-(((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate hemisulfate


InChi Code: InChI=1S/2C24H33FN7O7P.H2O4S/c2*1-13(2)37-21(34)14(3)31-40(35,39-15-9-7-6-8-10-15)36-11-16-18(33)24(4,25)22(38-16)32-12-28-17-19(27-5)29-23(26)30-20(17)32;1-5(2,3)4/h2*6-10,12-14,16,18,22,33H,11H2,1-5H3,(H,31,35)(H3,26,27,29,30);(H2,1,2,3,4)/t2*14-,16+,18+,22+,24+,40-;/m00./s1

SMILES Code: C[C@@H](C(OC(C)C)=O)N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@H](N3C=NC4=C(NC)N=C(N)N=C34)[C@](C)(F)[C@@H]2O)=O.C[C@@H](C(OC(C)C)=O)N[P@@](OC5=CC=CC=C5)(OC[C@H]6O[C@@H](N7C=NC8=C(NC)N=C(N)N=C78)[C@](C)(F)[C@@H]6O)=O.O=S(O)(O)=O

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001