Pralsetinib, CAS 2097132-94-8

  • Pralsetinib, CAS 2097132-94-8

Pralsetinib, CAS 2097132-94-8
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 2097132-94-8
  • Stock: 1.50kg
  • Assay: 99.45%

Pralsetinib, CAS 2097132-94-8

Pralsetinib, CAS 2097132-94-8Stock 1500g, Assay 98.67%, White powderWater 0.29%, Single Impurity 0.64%.


Pralsetinib, also known as BLU-667, is a highly potent, selective, next generation RET inhibitor with IC50 of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion.. BLU-667 is a potent and selective inhibitor of RET mutations, fusions, and predicted resistant mutants. RET fusions are key drivers of multiple cancers, including lung and thyroid cancer, and our research suggests that RET also plays a key role in some colon and breast cancers. By simultaneously targeting the primary driver and predicted resistant mutants that render cancer cells insensitive to treatment with currently approved drugs.

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Product Details:

Name: Pralsetinib

CAS#: 2097132-94-8

Chemical Formula: C27H32FN9O2

Exact Mass: 533.2663

Molecular Weight: 533.6124

Elemental Analysis: C, 60.77; H, 6.04; F, 3.56; N, 23.62; O, 6.00


Synonym: Pralsetinib; BLU-667; BLU 667; BLU667;

IUPAC/Chemical Name: cis-N-{(1S)-1-[6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethyl}-1-methoxy-4-{4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}cyclohexane-1-carboxamide


InChi Code: InChI=1S/C27H32FN9O2/c1-16-11-23(33-25(32-16)19-7-9-27(39-4,10-8-19)26(29)38)37(24-12-17(2)34-35-24)18(3)20-5-6-22(30-13-20)36-15-21(28)14-31-36/h5-6,11-15,18-19H,7-10H2,1-4H3,(H2,29,38)(H,34,35)/t18-,19-,27+/m0/s1

SMILES Code: O=C([C@@]1(OC)CC[C@@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[C@H](C4=CC=C(N5N=CC(F)=C5)N=C4)C

Appearance: White powder

Purity: >99%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001