CAS 2097132-94-8: Pralsetinib (BLU-667)
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Pralsetinib (BLU-667), CAS 2097132-94-8

Pralsetinib (BLU-667), CAS 2097132-94-8, Stock 102g, Assay 99.71%, White powder, EOS is one of TOP GMP manufacturer

Pralsetinib (BLU-667)

Pralsetinib, also known as BLU-667, is a highly potent, selective, next generation RET inhibitor with IC50 of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion.. BLU-667 is a potent and selective inhibitor of RET mutations, fusions, and predicted resistant mutants. RET fusions are key drivers of multiple cancers, including lung and thyroid cancer, and our research suggests that RET also plays a key role in some colon and breast cancers. 

Product Details:

Name: Pralsetinib
CAS#: 2097132-94-8 (free base)
Chemical Formula: C27H32FN9O2
Exact Mass: 533.2663
Molecular Weight: 533.6124
Elemental Analysis: C, 60.77; H, 6.04; F, 3.56; N, 23.62; O, 6.00

Specification:

Synonym: Pralsetinib; BLU-667; BLU 667; BLU667;
IUPAC/Chemical Name: cis-N-{(1S)-1-[6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethyl}-1-methoxy-4-{4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}cyclohexane-1-carboxamide
InChi Key: MXSCYXULRDBMTH-RWYJCYHVSA-N
InChi Code: InChI=1S/C27H32FN9O2/c1-16-11-23(33-25(32-16)19-7-9-27(39-4,10-8-19)26(29)38)37(24-12-17(2)34-35-24)18(3)20-5-6-22(30-13-20)36-15-21(28)14-31-36/h5-6,11-15,18-19H,7-10H2,1-4H3,(H2,29,38)(H,34,35)/t18-,19-,27+/m0/s1
SMILES Code: O=C([C@@]1(OC)CC[C@@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[C@H](C4=CC=C(N5N=CC(F)=C5)N=C4)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
HS Tariff Code: 2934.99.9001

Certification: