Lonafarnib, CAS 193275-84-2

  • Lonafarnib, CAS 193275-84-2

Lonafarnib, CAS 193275-84-2
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 193275-84-2
  • Stock: 779g
  • Assay: 98.54%

Lonafarnib, CAS 193275-84-2

Lonafarnib, CAS 193275-84-2Stock 779g, Assay 98.54%, White powderWater 0.44%, Single Impurity 0.32%.


Lonafarnib

Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers.



Product Details:

Name: Lonafarnib

CAS#: 193275-84-2

Chemical Formula: C27H31Br2ClN4O2

Exact Mass: 636.05023

Molecular Weight: 638.82

Elemental Analysis: C, 50.76; H, 4.89; Br, 25.02; Cl, 5.55; N, 8.77; O, 5.01



Specification:

Synonym: SCH 66336; SCH-66336; SCH66336; Lonafarnib; US brand name: Sarasar.

IUPAC/Chemical Name: 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxamide.

InChi Key: DHMTURDWPRKSOA-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)

SMILES Code: O=C(N1CCC(CC(N2CCC(C3C4=C(Br)C=C(Cl)C=C4CCC5=CC(Br)=CN=C53)CC2)=O)CC1)N

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: