L-778123, CAS 183499-57-2
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L-778123, CAS 183499-57-2

L-778123, CAS 183499-57-2, Stock 945g, Assay 98.14%, White powder, Water 0.37%, Single Impurity 0.26%.

L-778123

L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination ofL-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.

Product Details:

Name: L-778123 free base

CAS#: 183499-57-2 (free base)

Chemical Formula: C22H20ClN5O

Exact Mass: 405.1356

Molecular Weight: 405.88

Elemental Analysis: C, 65.10; H, 4.97; Cl, 8.73; N, 17.25; O, 3.94

Specification:

Synonym: L-778123 free base; L-778123; L 778123; L778123; L-778,123; L 778,123; L778,123;

IUPAC/Chemical Name: 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile

InChi Key: JNUGFGAVPBYSHF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2

SMILES Code: N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: