Zosuquidr.3HCl(LY335979), CAS 167465-36-3
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CAS Number: 167465-36-3
Stock: 892g
Assay: 98.64%

Zosuquidr.3HCl(LY335979), CAS 167465-36-3

Zosuquidr.3HCl(LY335979), CAS 167465-36-3, Stock 892g, Assay 98.64%, White powder, Water 0.24%, Single Impurity 0.32%.

Zosuquidar trihydrochloride

Zosuquidar, also known as LY-335979, is a potent P-glycoprotein (P-gp) inhibitor, which binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents.

Product Details:

Name: Zosuquidar trihydrochloride
CAS#: 167465-36-3 ( HCl)
Chemical Formula: C32H34Cl3F2N3O2
Exact Mass:
Molecular Weight: 637.0
Elemental Analysis: C, 60.34; H, 5.38; Cl, 16.70; F, 5.97; N, 6.60; O, 5.02

Specification:

Related CAS #: 167465-36-3 ( HCl) 167354-41-8 (free base)
Synonym: LY 335979; LY-335979; LY335979; D06387; RS33295198; Zosuquidar HCl; Zosuquidar 3HCl; Zosuquidar trihydrochloride
IUPAC/Chemical Name: (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol, trihydrochloride
InChi Key: ZPFVQKPWGDRLHL-WITOOOCMSA-N
InChi Code: InChI=1S/C32H31F2N3O2.3ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;;;/h1-14,21,29-31,38H,15-20H2;3*1H/t21-,29-,30+,31-;;;/m1.../s1
SMILES Code: O[C@@H](COC1=C2C=CC=NC2=CC=C1)CN3CCN([C@@H]4C5=CC=CC=C5[C@]6([H])[C@](C6(F)F)([H])C7=CC=CC=C74)CC3.[H]Cl.[H]Cl.[H]Cl
Appearance: white powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >10 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00