Vorasidenib, CAS 1644545-52-7

  • Vorasidenib, CAS 1644545-52-7

Vorasidenib, CAS 1644545-52-7
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1644545-52-7
  • Stock: 779g
  • Assay: 98.54%

Vorasidenib, CAS 1644545-52-7

Vorasidenib, CAS 1644545-52-7Stock 779g, Assay 98.54%, White powderWater 0.24%, Single Impurity 0.32%.


AG-881

Vorasidenib, also known as AG-881, is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. AG-881 specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH mutations.


Product Details:

Name: Vorasidenib

CAS#: 1644545-52-7

Chemical Formula: C14H13ClF6N6

Exact Mass: 414.0794

Molecular Weight: 414.7404

Elemental Analysis: C, 40.54; H, 3.16; Cl, 8.55; F, 27.48; N, 20.26


Specification:

Synonym: Vorasidenib, AG-881, AG 881, AG881

IUPAC/Chemical Name: 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine

InChi Key: QCZAWDGAVJMPTA-RNFRBKRXSA-N

InChi Code: InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1

SMILES Code: C[C@@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[C@H](C)C(F)(F)F)=N1)C(F)(F)F

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: