ITI-214(phosphate), CAS 1642303-38-5

  • ITI-214(phosphate), CAS 1642303-38-5

ITI-214(phosphate), CAS 1642303-38-5
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  • CAS Number: 1642303-38-5
  • Stock: 841g
  • Assay: 98.83%

ITI-214(phosphate), CAS 1642303-38-5

ITI-214(phosphate), CAS 1642303-38-5, Stock 841g, Assay 98.83%, White powder, Water 0.14%, Single Impurity 0.32%.


ITI-214

ITI-214 is an orally active, potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. ITI-214 exhibited picomolar inhibitory potency for PDE1, demonstrated excellent selectivity against all other PDE families, and showed good efficacy in vivo. Currently, this investigational new drug is in Phase I clinical development and being considered for the treatment of several indications including cognitive deficits associated with schizophrenia and Alzheimer's disease, movement disorders, attention deficit and hyperactivity disorders, and other CNS and non-CNS disorders.


Product Details:

Name: ITI-214 phosphate

CAS#: 1642303-38-5 (phosphate)

Chemical Formula: C29H29FN7O5P

Exact Mass:

Molecular Weight: 605.5672

Elemental Analysis: C, 57.52; H, 4.83; F, 3.14; N, 16.19; O, 13.21; P, 5.11



Specification:

Related CAS #: 1642303-38-5 (phosphate)   1160521-50-5 (free base)    

Synonym: ITI-214; ITI 214; ITI214; ITI-214 phosphate salt.

IUPAC/Chemical Name: (6aR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one phosphate

InChi Key: ZPIAAFIYOPWWJL-RFPXDPOKSA-N

InChi Code: InChI=1S/C29H26FN7O.H3O4P/c1-35-28(38)25-26(31-20-7-3-2-4-8-20)36(34-27(25)37-23-11-5-10-22(23)33-29(35)37)17-18-13-15-19(16-14-18)21-9-6-12-24(30)32-21;1-5(2,3)4/h2-4,6-9,12-16,22-23,31H,5,10-11,17H2,1H3;(H3,1,2,3,4)/t22-,23+;/m1./s1

SMILES Code: O=C(C1=C(NC2=CC=CC=C2)N(CC3=CC=C(C4=NC(F)=CC=C4)C=C3)N=C1N56)N(C)C5=N[C@@]7([H])[C@]6([H])CCC7.O=P(O)(O)O

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: