AZD3759, CAS 1626387-80-1

  • AZD3759, CAS 1626387-80-1

AZD3759, CAS 1626387-80-1
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1626387-80-1
  • Stock: 794g
  • Assay: 98.26%

AZD3759, CAS 1626387-80-1

AZD3759, CAS 1626387-80-1, Stock 794g, Assay 98.26%, White powderWater 0.47%, Single Impurity 0.63%.


AZD3759

AZD3759 is also known as zorifertinib. It is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.


Product Details:

Name: AZD3759

CAS#: 1626387-80-1

Chemical Formula: C22H23ClFN5O3

Exact Mass: 459.14735

Molecular Weight: 459.91

Elemental Analysis: C, 57.46; H, 5.04; Cl, 7.71; F, 4.13; N, 15.23; O, 10.44


Specification:

Synonym: AZD3759; AZD-3759; AZD 3759; zorifertinibum; zorifertinib.

IUPAC/Chemical Name: (R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate

InChi Key: MXDSJQHFFDGFDK-CYBMUJFWSA-N

InChi Code: InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1

SMILES Code: O=C(N1[C@H](C)CN(C)CC1)OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: