TIC10, CAS 1616632-77-9
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- CAS Number: 1616632-77-9
- Stock: 841g
- Assay: 98.64%
TIC10, CAS 1616632-77-9
TIC10, CAS 1616632-77-9, Stock 841g, Assay 98.64%, White powder, Water 0.24%, Single Impurity 0.32%.
ONC-201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.
Name: ONC-201 (TIC-10)
CAS#: 1616632-77-9 (free base)
Chemical Formula: C24H26N4O
Exact Mass: 386.21066
Molecular Weight: 386.49
Elemental Analysis: C, 74.58; H, 6.78; N, 14.50; O, 4.14
Related CAS #: 41276-02-2 (TIC10 isomer) 1616632-77-9 (free base) 1638178-82-1 (HCl) 1777785-71-3 (HBr) 2007141-57-1 (2HBr)
Synonym: ONC201; ONC 201; ONC-201; NSC350625; NSC-350625; NSC 350625; TIC10; TIC 10; TIC-10; TRAIL inducing compound 10; imipridone
IUPAC/Chemical Name: 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one
InChi Key: VLULRUCCHYVXOH-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3
SMILES Code: O=C1N(CC2=CC=CC=C2C)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4
Appearance: White powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not soluble in water
Shelf Life: >2 years if stored properly
Drug Formulation: TIC10 is not water soluble, may be dissolved in DMSO, then is formulated in 20% Cremophor EL, 10% DMSO, and 70% PBS buffer.
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001