15810736 CAS 1608125-21-8: AMG-319 | ACP319

CAS 1608125-21-8: AMG-319

  • CAS 1608125-21-8: AMG-319

CAS 1608125-21-8: AMG-319
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  • CAS Number: 1608125-21-8
  • Stock: 798g
  • Assay: 98.36%

AMG-319, CAS 1608125-21-8

AMG-319, CAS 1608125-21-8, Stock 798g, Assay 98.36%, White powder, Water 0.72%, Single Impurity 0.19%.


AMG-319

AMG-319, also known as ACP319, is a highly selective, potent, and orally bioavailable small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. PI3K-delta inhibitor AMG 319 prevents the activation of the PI3K signaling pathway through inhibition of the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), thus decreasing proliferation and inducing cell death. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.


Product Details:

Name: AMG-319

CAS#: 1608125-21-8

Chemical Formula: C21H16FN7

Exact Mass: 385.14512

Molecular Weight: 385.41

Elemental Analysis: C, 65.45; H, 4.18; F, 4.93; N, 25.44


Specification:

Synonym: AMG319; AMG-319; AMG 319; ACP319; ACP-319; ACP 319;

IUPAC/Chemical Name: (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine

InChi Key: KWRYMZHCQIOOEB-LBPRGKRZSA-N

InChi Code: InChI=1S/C21H16FN7/c1-12(28-21-19-20(25-10-24-19)26-11-27-21)15-8-13-5-6-14(22)9-17(13)29-18(15)16-4-2-3-7-23-16/h2-12H,1H3,(H2,24,25,26,27,28)/t12-/m0/s1

SMILES Code: C[C@H](NC1=C2N=CNC2=NC=N1)C3=CC4=CC=C(F)C=C4N=C3C5=NC=CC=C5

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: