CAS 159858-22-7: Fmoc-Val-Cit-PAB-OH
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Fmoc-Val-Cit-PAB-OH, CAS 159858-22-7:

Fmoc-Val-Cit-PAB-OH, CAS 159858-22-7, Stock 206g, Assay 99.13%, White powder, Water 0.26%, Single Impurity 0.17%.

Fmoc-Val-Cit-PAB-OH

Fmoc-Val-Cit-PAB-OH is a useful heterobifunational linker for making Antibody-Drug-Conjugates (ADC) for targeting drug delivery. The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome, the ADC payload will only be released in the cell. The azido group will react with DBCO, BCN or other Alkyne group through click chemistry. The PEG spacer increases aqueous solubility.

Product Details:

Name: Fmoc-Val-Cit-PAB-OH

CAS#: 159858-22-7

Chemical Formula: C33H39N5O6

Exact Mass: 601.29

Molecular Weight: 601.704

Elemental Analysis: C, 65.87; H, 6.53; N, 11.64; O, 15.95

Specification:

Synonym: Fmoc-Val-Cit-PAB-OH; ADC linker.

IUPAC/Chemical Name: (9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

InChi Key: DALMAZHDNFCDRP-VMPREFPWSA-N

InChi Code: InChI=1S/C33H39N5O6/c1-20(2)29(38-33(43)44-19-27-25-10-5-3-8-23(25)24-9-4-6-11-26(24)27)31(41)37-28(12-7-17-35-32(34)42)30(40)36-22-15-13-21(18-39)14-16-22/h3-6,8-11,13-16,20,27-29,39H,7,12,17-19H2,1-2H3,(H,36,40)(H,37,41)(H,38,43)(H3,34,35,42)/t28-,29-/m0/s1

SMILES Code: O=C(N)NCCC[C@H](NC([C@H](C(C)C)NC(OCC1C(C=CC=C2)=C2C3=C1C=CC=C3)=O)=O)C(NC4=CC=C(CO)C=C4)=O

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2924297790

Certification: