CAS 159857-80-4: Mc-Val-Cit-PAB
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- CAS Number: 159857-80-4
- Stock: 176g
- Assay: 99.11%
Mc-Val-Cit-PAB, CAS 159857-80-4:
Mc-Val-Cit-PAB, CAS 159857-80-4, Stock 176g, Assay 99.11%, White powder, Water 0.23%, Single Impurity 0.17%.
Mc-Val-Cit-PAB
Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds, such as anticancer agents. Mc-Val-Cit-PAB is cleaved in vivo by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the ADC to cancer cells.
Product Details:
Name: Mc-Val-Cit-PAB
CAS#: 159857-80-4 (MC-Val-Cit-PAB)
Chemical Formula: C28H40N6O7
Exact Mass: 572.2958
Molecular Weight: 572.663
Elemental Analysis: C, 58.73; H, 7.04; N, 14.68; O, 19.56
Specification:
Related CAS #: 159857-80-4 (MC-Val-Cit-PAB) 159857-81-5 (MC-Val-Cit-PAB-PNP) 159857-79-1 (Val-cit-PAB-OH)
Synonym: Mc-Val-Cit-PAB
IUPAC/Chemical Name: N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
InChi Key: UMDCMQHPXQLHGR-OFVILXPXSA-N
InChi Code: InChI=1S/C28H40N6O7/c1-18(2)25(32-22(36)8-4-3-5-16-33-23(37)13-14-24(33)38)27(40)34(20-11-9-19(17-35)10-12-20)21(26(29)39)7-6-15-31-28(30)41/h9-14,18,21,25,35H,3-8,15-17H2,1-2H3,(H2,29,39)(H,32,36)(H3,30,31,41)/t21-,25-/m0/s1
SMILES Code: O=C(N)[C@H](CCCNC(N)=O)N(C([C@H](C(C)C)NC(CCCCCN1C(C=CC1=O)=O)=O)=O)C2=CC=C(CO)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
Certification:
