CAS 1595129-71-7: ME-401
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- CAS Number: 1595129-71-7
- Stock: 256g
- Assay: 99.13%
ME-401, CAS 1595129-71-7:
ME-401, CAS 1595129-71-7, Stock 256g, Assay 99.13%, White powder, Water 0.29%, Single Impurity 0.16%.
Zandelisib, also known as PWT143 and ME-401, is an orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, PI3K-delta inhibitor PWT143 selectively inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key role in the proliferation and survival of hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
CAS#: 1595129-71-7 (free base)
Chemical Formula: C31H40N8O3S
Exact Mass: 604.2944
Molecular Weight: 604.774
Elemental Analysis: C, 61.57; H, 6.67; N, 18.53; O, 7.94; S, 5.30
Related CAS #: 1595129-71-7 (free base) Zandelisib HCl Zandelisib mesylate
Synonym: PWT143; PWT-143; PWT 143; ME-401; ME401; ME 401; Zandelisib;
IUPAC/Chemical Name: N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-4-(2-(methylsulfonyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine
InChi Key: PGTXVGREXBMCCY-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H40N8O3S/c1-31(2,21-23-9-5-6-10-24(23)22-13-15-37(3)16-14-22)36-27-33-28(38-17-19-42-20-18-38)35-29(34-27)39-26-12-8-7-11-25(26)32-30(39)43(4,40)41/h5-12,22H,13-21H2,1-4H3,(H,33,34,35,36)
SMILES Code: CN(CC1)CCC1C2=C(CC(C)(C)NC3=NC(N4CCOCC4)=NC(N5C(S(C)(=O)=O)=NC6=C5C=CC=C6)=N3)C=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001